What's With Andy? premiered on ABC Family Channel on September 22, 2001. Some kids want to rule the playground, some bust their brains for good grades, but Andy is a little different. He hopes to be the world's greatest practical joker. Sometimes things don't go his way. Like the time Andy decided to mimic his sister and went to a school dance... in a dress. Is he on his way to becoming a practical joke artist, or will he be seen as just another class clown? The series is inspired by the popular book series by Andy Griffiths.